Diagnostic performance of serum cystatin C and complement component 1q in lupus nephritis
نویسندگان
چکیده
منابع مشابه
Complement in Lupus Nephritis
The complement cascade consists of a series of plasma proteins that not only play a vital role in destroying pathogens but also mediate humoral and cellular interactions within the immune system (Figure). Recent work, driven particularly by the availability of gene-targeted mice, has considerably increased our understanding of the links between the complement system and glomerular disease. In t...
متن کاملComplement in Lupus Nephritis
The complement cascade consists of a series of plasma proteins that not only play a vital role in destroying pathogens but also mediate humoral and cellular interactions within the immune system (Figure). Recent work, driven particularly by the availability of gene-targeted mice, has considerably increased our understanding of the links between the complement system and glomerular disease. In t...
متن کاملSerum Beta 2-Microglobulin/Cystatin C Index: A Useful Biomarker in Lupus Nephritis?
BACKGROUND Systemic lupus erythematosus (SLE) is a chronic multisystem autoimmune disease with frequent flares. Our aim was to evaluate the beta 2-microglobulin/cystatin C (β2M/CysC) index versus other markers as a predictor factor for assessment of SLE reactivation. METHODS We prospectively analyzed 42 patients with lupus nephritis. Disease activity was classified using SLEDAI-2K and BILAG. ...
متن کاملComplement 1q (C1q) antibodies levels in sera of Egyptian patients with lupus nephritis.
Renal involvement is common in systemic lupus erythematosus (SLE). Anti-C1q antibodies are associated with SLE nephritis. This study attempted to correlate anti-C1q levels to different types of lupus nephritis (LN). Anti-C1q antibodies were assessed in two groups (15 subjects each) of SLE patients with and without LN. Ten apparently healthy volunteers served as controls. The sensitivity of anti...
متن کاملThe Complement System in Lupus Nephritis.
The complement system is composed of a family of soluble and membrane-bound proteins that historically has been viewed as a key component of the innate immune system, with a primary role of providing a first-line defense against microorganisms. Although this role indeed is important, complement has many other physiological roles, including the following: (1) influencing appropriate immune respo...
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ژورنال
عنوان ژورنال: Arthritis Research & Therapy
سال: 2019
ISSN: 1478-6362
DOI: 10.1186/s13075-019-2065-x